Marjan Rupnik, Ph.D.

Professor and Head,
Institute of Physiology
Medical faculty University of Maribor

- BSc Biology/Physiology, University of Ljubljana, Slovenia, 1991
- MSc, Physiology, Medical faculty, University of Ljubljana, 1993
- PhD, Cell Physiology, Medical faculty, University of Ljubljana, 1996
- Assistant Professor of Pathophysiology, Medical faculty, University of Ljubljana, 1997
- Group leader, Department of Neuroendocrinology, European Neuroscience Institute/Max- Planck-Institute for Biophysical Chemistry, Goettingen, Germany, 2000-2005
- Associate Professor of Physiology, Faculty of Medicine  University of Maribor, 2004
- Full Professor of Physiology, Faculty of Medicine, University of Maribor, 2009
- IUPS Council member, since 2007
- CO CIPKeBiP, since 2009

Last modified:  March 2010

fax: +386 2 330 5853

Interview Zdravstveni vestnik

skype: marjan.rupnik

RECENT PUBLICATIONS:

 Paulmann N, Grohmann M, Voigt JP, Bert B, Vowinckel J, Bader M, Skelin M, Jevsek M, Fink H, Rupnik M, Walther DJ. Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation. PLoS Biol. 2009 Oct;7(10):e1000229.

 Sedej S, Gurung IS, Binz T, Rupnik M (2009) Phosphatidylinositol-4,5-bisphosphate-dependent facilitation of the ATP-dependent secretory activity in mouse pituitary cells. Ann N Y Acad Sci. 1152:165-73.

 Rozzo A, Meneghel-Rozzo T, Delakorda SL, Yang SB, Rupnik M (2009) Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas. Ann N Y Acad Sci. 1152:53-62.

 Rupnik M (2009) The physiology of rodent beta-cells in pancreas slices. Acta Physiol (Oxf). 195(1):123-38.

 Cocucci E, Racchetti G, Rupnik M, Meldolesi J (2008) The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4. J Cell Sci.121(Pt 18):2983-91.

 Rose T, Efendic S, Rupnik M (2007) Ca²⁺-secretion coupling is impaired in diabetic Goto Kakizaki rats. J Gen Physiol. 129(6):493-508.

 Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M (2007) Cx36-Mediated Coupling Reduces beta-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics. Diabetes. 56(4):1078-86.

 Dudanova I, Sedej S, Ahmad M, Masius H, Sargsyan V, Zhang W, Riedel D, Angenstein F, Schild D, Rupnik M, Missler M (2006) Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci. 26(41):10599-613.

 Rupnik M, Kreft M, Nothias F, Grilc S, Bobanovic LK, Johannes L, Kiauta T, Vernier P, Darchen F, Zorec R (2006) Distinct role of Rab3A and Rab3B in secretory activity of rat melanotrophs. Am J Physiol Cell Physiol. 292(1):C98-105.

 Kreft M, Blaganje M, Grilc S, Rupnik M, Zorec R. Glutamate stimulation increases hormone release in rat melanotrophs. Neurosci Lett. 404(3):299-302.

 Yang S-B, Major F, Tietze LT, Rupnik M (2005) Block of delayed-rectifier potassium channels by reduced-haloperidol and related compounds in mouse cortical neurons. (2005) J Pharmacol Exp Ther. 315(1):352-362.

 Sedej S, Rose T, Rupnik M (2005) cAMP increases Ca²⁺-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices. J Physiol. 567(3):799-813.

 Turner J-E, Sedej S, Rupnik M (2005) Cytosolic Cl- ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices. J Physiol. 566(2):443-453.

 Speier S, Yang S-B, Sroka K, Rose T, Rupnik M. (2005) K_ATP channels in beta-cells in pancreatic slices are directly modulated by millimolar ATP. Mol Cell Endocrinol. 230(1-2):51-8.

 Rupnik M, Pabst S, Rupnik M, von Eichel-Streiber C, Urlaub H, Soling HD. (2005) Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells. Microbiology. 151(Pt 1):199-208.

 Sedej, S., Rupnik, M., Zorec, R. (2005) Endocytosis requires Rab5 protein in rat melanotrophs (2005) Ann NY Acad Sci 1948:272-280.

 Blyszczuk P, Asbrand C, Rozzo A, Kania G, St-Onge L, Rupnik M, Wobus AM. (2005) Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Int J Dev Biol. 48(10):1095-104.

 Cocucci E, Racchetti G, Podini P, Rupnik M, Meldolesi J. (2004) Enlargeosome, an Exocytic Vesicle Resistant to Non-Ionic Detergents, Undergoes Endocytosis via a Non-Acidic Route. Mol Biol Cell. 15(12):5356-68.

 Petrovič U, Šribar J, Pariš A, Rupnik M, Limpel-Kržan M, Vardjan N, Gubenšek F, Zorec R, Križaj I (2004) Ammodytoxin, a neurotoxic secretory phospholipase A₂, can act in the cytosol of the nerve cell, Biochem Biophys Res Comm, 324:981-985.

 Yang S-B, Proks P, Ashcroft F M, Rupnik M. (2004) Inhibition of ATP-sensitive potassium channels by haloperidol. Br J Pharmacol. 143(8):960-7

 Meneghel-Rozzo, T., Rozzo, A., Poppi, L., Rupnik, M. (2004) In vivo and in vitro  development of mouse pancreatic β-cells in the organotypic slices. Cell Tiss Res, 316:295-303.

 Kreft, M., Stenovec, M., Rupnik, M., et al.. (2004) Properties of Ca²⁺-dependent exocytosis in cultured astrocytes. Glia, 46 (4): 437-445.

 Sedej, S., Tsujimoto, T., Zorec, R., Rupnik, M. (2004) Voltage-activated Ca²⁺ channels and their role in the endocrine function of the pituitatry gland in newborn and adult mice. J Physiol., 555.3: 769-782.

 Speier, S, Rupnik, M. (2003) A novel approach to in situ characterization of pancreatic b-cells. Pflugers Arch-Eur J Physiol 446(5) 553-558.

CONTACT INFORMATION:

Prof. Dr. Marjan Rupnik
Institute of Physiology
Faculty of Medicine University of Maribor
Slomskov trg 15
2000 Maribor
Slovenia

phone: +386 2 330 5854
fax:   +386 2 330 5853
email: najramkinpur@gmail.com

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